Yohimbine

yohimbe

Yohimbine. Active: Yohimbine Hydrochloride

Dose

Start on 0.25ml (25mg) per day and slowly increase to 0.75ml (75mg) per day

Yohimbine Hydrochloride History and Overview

Yohimbe with its active ingredient yohimbine has been the subject of some intense debates among fitness enthusiasts and industry insiders alike. Originally considered a flop of a supplement, because it did not increase testosterone levels as suspected. It did develop a cult following by some men for its reported ability to increase sexual vigor.

However, some supplement manufacturers claimed aided in the loss of “stubborn fat. Those areas are located in the midsection of men, and on the glutes and thighs of women.

Yohimbe is a small evergreen tree native to Africa, and the scientific name is Pausinystalia Yohimbe. The bark contains yohimbine and other substance known as indole alkaloids.

Yohimbine is a pre-synaptic alpha-2-adrenergic blocking agent, also referred to as an alpha 2-adrenergic antagonist. This action increases sympathetic nervous system activity and can cause increased amounts of epinephrine (also known as adrenaline) and norepinephrine in the bloodstream. It involves the sympathetic nervous system that controls the body’s response to stress and also triggers the fight-or-flight response.

The effects of epinephrine and norepinephrine on the body include increased blood pressure and heart rate. In low dosages, yohimbine may help support healthy blood pressure. This may be due to blood vessels dilating reducing vascular resistance. This central nervous system stimulation causes anxiety in some people.

Yohimbine And Weight Loss

The use of yohimbine for weight loss is inconclusive. Alpha-2 receptors are common in sites of the body that accumulate fat; abdomen, breasts, buttocks, and thighs. When exposed to circulating catecholamines, such as norepinephrine and epinephrine, alpha-2 receptor sites inhibit lipolysis (the release of fatty acids), while the beta receptors stimulate lipolysis.

Epinephrine, norepinephrine, glucagon, adrenocorticotropic hormone (ACTH), and growth hormone stimulate the release of fatty acids from adipose tissue into the bloodstream. These fatty acids are quickly oxidized while on low-calorie diets.

When fatty acid blood concentration is high, it favors fat storage, which results from over-eating and inactivity. Although we always use fatty acids for energy, the amount we use for energy determines the amount stored as fat. This is a rather simplistic explanation of fatty acid metabolism.

Blocking the alpha-2 receptors might be useful during weight loss. It frees up the catecholamines like norepinephrine, making it more available to stimulate beta-receptor sites. This results in a higher rate of lipolysis. Also, yohimbine increase levels of norepinephrine in the bloodstream.

Yohimbine For Supporting Sexual Health

In the 1960s, studies conducted using a combination supplement called Nux Vomica, which contained yohimbine and methyltestosterone. Nux Vomica was effective after 2 to 3 weeks of use in most cases but they observed various side effects. There no conclusive studies to date.

Serious side effects observed in these short-term studies were infrequent and reversible. These include: nervousness, irritability, insomnia, headache, skin flushing, anorexia, nausea, gastric distress, diarrhea, vomiting, palpitations, tachycardia, dysuria, pain, increased blood pressure, dizziness, sweating, weight gain, constipation, and anxiety. Always consult your doctor when using yohimbine-containing products.

Yohimbe/Caffeine Stacks

Some studies have shown increased fat burning effects of Yohimbe when used in combination with other compounds. It is difficult to say if this is in fact accurate. The use of stacks are widespread today with the main one including Yohimbe being the Yohimbe/Clenbuterol/LT-3 stack also knows as CYT3

Side Effects

Side effects are worse than those of clenbuterol. Increased heart rate, vomiting, nausea, and insomnia are possible. Dosages should be conservative. Athletes should start on 0.25ml (25mg) per day. Then increase to 0.75ml (75mg) per day. Increasing the dose should be gradual. The reduction of receptor sensitivity happens fast with this substance. The use of intermittent cycles will yield better results. Zaditen (ketotifen) does not “free” receptors for yohimbine, as with Clenbuterol. 

Do not use while taking any medications, or if other medical problems exist, such as angina pectoris, depression, other psychiatric illness, heart disease, high blood pressure, kidney disease, or liver disease. Do not exceed the recommended dosage for Yohimbine, as an overdose could, in extreme cases, result in death.

Yohimbine is best taken on an empty stomach, so no insulin is present. Insulin reduces Yohimbe effects when present. Administration in the morning on an empty stomach yields the greatest effect. Although Yohimbine Hydrochloride will work best in a fasting state, you can take a serving of whey protein before your cardio training. Whey protein will not spike insulin enough to reduce the effects. The best time to take Yohimbine is before low-to-moderate intensity cardio workouts.

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