Timoxifen or Nolvadex. Active: Timoxifen Citrate
This remedy is somewhat different from others since it is not an anabolic/androgenic steroid. For male and female bodybuilders, however, it is a very useful and recommended compound which is conﬁrmed by its widespread use and mostly positive results. Timoxifen belongs to the group of sex hormones and is a so-called anti-estrogen. The normal application of Timoxifen is in the treatment of certain forms of breast cancer in female patients. With Timoxifen it is possible to reverse an existing growth process of deceased tissue and prevent further growth. The growth of certain tissues is stimulated by the body’s own estrogen hormone. This is especially true for the breast glands in men and women since the body has a large number of estrogen receptors at these glands which can bond with the estrogens present in the blood. If the body’s own estrogen level is unusually high an undesired growth of breast glands occurs. However, in healthy women and particularly in men this is not the case. Despite this, it is mostly male bodybuilders who use Timoxifen, and fewer women.
At first sight this seems somewhat inconceivable but when taking a closer look, the reasons are clear. Bodybuilders who take Timoxifen also use anabolic steroids at the same time. Since most steroids aromatize more or less strongly, i.e. part of the substance is converted into estrogens, male bodybuilders can experience a significant elevation in the normally very low estrogen level. This can lead to feminization symptoms such as gynecomastia (growth of breast glands), increased fat deposits and higher water retention.
The anti-estrogen Timoxifen works against this by blocking the estrogen receptors of the effected body tissue, thereby inhibiting a bonding of estrogens and receptor. It is, however, important to understand that Timoxifen does not prevent the aromatization but only acts as an estrogen antagonist. This means that it does not prevent testosterone and its synthetic derivatives (steroids) from converting into estrogens but only fights with them in a sort of ”competition” for the estrogen receptors. This characteristic has the disadvantage that after the discontinuance of Timoxifen a ”rebound effect” can occur which means that the suddenly freed estrogen receptors are now able to absorb the estrogen present in the blood. For this reason the combined intake of Proviron is suggested (see Proviron.)
Nolvadex is also useful during a diet since it helps in the burning of fat. Although Nolvadex has no direct fat-burning effect its anti-estrogenic effect contributes to keeping the estrogen level as low as possible. Nolvadex should especially be taken together with the strong androgenic steroids Dianabol and Anadrol 50, and the various testosterone compounds. Athletes who have a tendency to retain water and who have a mammary dysfunction should take Nolvadex as a prevention during every steroid intake. Since Nolvadex is very effective in most cases it is no wonder that several athletes can take Anadrol 50 and Dianabol until the day of a competition, and in combination with a diuretic still appear totally ripped in the limelight. Those who already have a low body fat content will achieve a visibly improved muscle hardness with Nolvadex.
Several bodybuilders like to use Nolvadex at the end of a steroid cycle since it counteracts the side effects caused by the estrogens. These can occur after the discontinuance of steroids when the androgen level in relationship to the estrogen concentration is too low and estrogen becomes the dominant hormone. A very rare but all the more serious problem of Nolvadex is that in some cases it does not lower the estrogen level but can increase it. The Canadian physician, Dr. Mauro G. Di Pasquale, in his book Drug Use and Detection in Amateur Sports, Update Five confirms this possibility: ”Recent studies have shown, however, that in a small number of people taking tamoxifen, the effect can be paradoxical. Instead of decreasing estrogen production, it can promote it; and instead of acting as an estrogen antagonist it can act as an agent. In these cases, for some unknown reason, adrenal DHEA production is dramatically increased. Since DHEA is a steroid precursor for peripheral estrogen (and testosterone) production, serum estrogen levels are increased and the higher serum levels overwhelm the tamoxifen which is binding to the central receptors. Apparently only a slight increase in the serum estrogen concentration is needed to overcome the anti-estrogen effects of tamoxifen.”
Another disadvantage is that it can weaken the anabolic effect of some steroids. The reason is that Nolvadex, as we know, reduces the estrogen level. The fact is, however, that certain steroids, especially the various testosterone compounds, can only achieve their full effect if the estrogen level is sufficiently high. Daniel Duchaine in his book Ask the Guru bolsters this thesis: ”But it (testosterone) is not anabolic in and of itself, because it requires the body to have a sufficient level of estrogen in order to achieve its fullest anabolic effect. This is why there is reduced anabolic activity from many steroids when Nolvadex (an estrogen antagonist, which is used primarily to prevent gynecomastia) is added to a steroid stack.”
Those who are used to the intake of larger amounts of various steroids do not have to worry about this. Athletes however, who predominantly use mild steroids such as Primabolan, Winstrol, Oxandrolone, and Deca should carefully consider whether or not they should take Nolvadex since, due to the compound’s already moderate anabolic effect, an additional loss of effect could take place, leading to unsatisfying results.
A rarely observed but welcome characteristic of Nolvadex is that it has a direct inﬂuence on the hypothalamus and thus, by an increased release of gonadotropine, it stimulates the testosterone production in the testes. This does not result in a tremendous but still a measurable increase of the body’s own testosterone. This effect, however, is not sufficient to significantly increase the testosterone production reduced by anabolic/androgenic steroids. Also the physician Dr. Mauro G. Di Pasquale whom we have mentioned several times, Anabolic Steroid Side Effects—Fact, Fiction and Treatment on page 29: ”However these compounds seem to have little effect on preventing the suppression of the HPTH while anabolic steroids are being used, perhaps because of an over riding direct suppression exerted by the anabolic steroids on the HPTA” For natural bodybuilders, however, use of Nolvadex, in this context, should be worth considering.
The side effects of Nolvadex are usually low in dosages of up to 30mg/day. In rare cases nausea, vomiting, hot ﬂashes, numbness, and blurred vision can occur. In women irregular menstrual cycles can occur which manifest themselves in weaker menstrual bleeding or even complete missing of a period. Women should also be careful not to get pregnant while taking Nolvadex. It is important for female athletes that Nolvadex and the “pill” not be taken together since the anti-estrogen Nolvadex and the estrogen-containing pill negatively counter-effect each other.The normal daily dosage taken by athletes corresponds more or less to the dosage indications of the manufacturer and is 10-30 mg/day. To prevent estrogenic side effects normally 10 mg/day are sufficient a dosage which also keeps low the risk of reducing the effect of simultaneously, taken steroids. Often it is sufficient if the athlete begins this preventive intake of Nolvadex only three to four weeks after the intake of anabolics.
Athletes who have tendencies toward gynecomastia, strong water retention, and increased fat deposits with steroids such as Dianabol, Testosterone, Anadrol 50, and Deca usually take 20-30mg/day. The combined application of Nolvadex 20-30 mg/day and Proviron 25-50 mg/day in these cases leads to excellent results. The same is true for athletes who are in competition, and for women. Women, however, should do without the intake of Proviron or at least reduce the dose to one 25 mg tablet per day. Unfortunately, in most cases, a very pronounced gynecomastia (”bitch tits”) cannot be reduced by taking Nolvadex so that often surgery is required, surgery which is not paid for by health insurance. First signs of a possible gynecomastia are light pain when touching the nipples.
The tablets are usually taken 1-2 tabs daily, swallowed whole without chewing, with some liquid during meals.