Growth Hormone. Active: Somatropin
”Wow, is this great stuff. It is the best drug for permanent muscle gains. This is the only drug that can remedy bad genetics as it will make anybody grow.Human Growth Hormone use is the biggest gamble that an athlete can take, as the side effects are irreversible. Even with all that, we LOVE the stuff.” (Daniel Duchaine, Underground Steroid Handbook, 1982.)
As with no other doping drug, human growth hormone is still surrounded by an aura of mystery. Some call it a wonder drug which causes gigantic strength and muscle gains in the shortest time. Others consider it completely useless in improving sports performance and argue that it only promotes the growth process in children with an early stunting of growth. Some are of the opinion that human growth hormone in adults cause severe bone deformities in the form of overgrowth of the lower jaw and extremities.
Generally speaking, which growth hormone should one take, the human form, the synthetically manufactured version, recombined or genetically produced form, and in which dosage? All this controversy about human growth hormone is so complex that the reader must have some basic information in order to understand them. Human growth hormone is a polypeptide hormone consisting of 191 amino acids. In humans it is produced in the hypophysis and released if there are the right stimuli (e.g. training, sleep, stress, low blood sugar level). It is now important to understand that the freed HGH (human growth hormone) itself has no direct effect but only stimulates the liver to produce and release insulin—like growth factors and somatomedins. These growth factors are then the ones that cause Various effects on the body.
The problem, however, is that the liver is only capable of producing a limited amount of these substances so that the effect is limited. If human growth hormone is injected they only stimulate the liver to produce and release these substances and thus, as already mentioned, have no direct effect.
During the mid 1980’s only the human, biologically—active form was available as exogenous source of intake. It was obtained from the hypophysis of dead corpses, an expensive and costly procedure. In 1985 the intake of human growth hormone was linked with the very rare Creutzfeld-Jakob disease, an invariably fatal brain disease characterized by progressive dementia. In response, manufacturers removed this version from the market. Today, human growth hormone is no longer available for injection. Fortunately, science has not been asleep and has developed the synthetic human growth hormone which is genetically produced either from Escherichia coli (E coli) or from the transformed mouse ceH line. It has been available in numerous countries for years (see list with trade names).
The use of these STH somatotropic hormone compounds offers the athlete three performance—enhancing effects. Human Growth Hormone (somatotropic hormone) has a strong anabolic effect and causes an increased protein synthesis which manifests itself in a muscular hypertrophy (enlargement of muscle cells) and in a muscular hyperplasia (increase of muscle cells.) The latter is very interesting since this increase cannot be obtained by the intake of steroids. This is probably also the reason why STH is called the strongest anabolic hormone.
The second effect of Human Growth Hormone is its pronounced inﬂuence on the burning of fat. It turns more body fat into energy, leading to a drastic reduction in fat or allowing the athlete to increase his caloric intake. Third, and often overlooked, is the fact that Human Growth Hormone strengthens the connective tissue, tendons, and cartilages, which could be one of the main reasons for the significant increase in strength experienced by many athletes.
When no benefits are experienced
Several bodybuilders and powerlifters report that through the simultaneous intake with steroids, Human Growth Hormone protects the athlete from injuries while increasing his strength. You will say that this sounds just wonderful. What is the problem, however, since there are still some who argue that Human Growth Hormone offers nothing to athletes? There are, by all means, several athletes who have tried Human Growth Hormone and who were sadly disappointed by its results. However, as with many things in life, there is a logical explanation or perhaps even more than one:
- The athlete simply has not taken a sufficient amount of human growth hormone regularly and over a long enough period of time. Human Growth Hormone is a very expensive compound and an effective dosage is unaffordable by most people.
- When using Human Growth Hormone the body also needs more thyroid hormones, insulin, corticosteroids, gonadotropins, estrogens and, what a surprise!, androgens and anabolics. This is also the reason why growth growth hormone, when taken alone, is considerably less effective and can only reach its optimum effect by the additive intake of steroids, thyroid hormones, and insulin, in particular. But we must point out in this case that human growth hormone has a predominantly anabolic effect. There are three hormones which are needed at the same time in order to allow for maximum anabolic effect.
According to statistics by the German Drug Administration, 42% of the Human Growth Hormone vials confiscated on the North American black market are fakes.” (Der Spiegel, no. 11, 1993.) One can only say, ”Poor Ben.” Even Deutsche Apothekerzeitung is aware of this problem. The magazine wrote in its issue no. 26 of 07/01/ 93 in the article ”Wachstumshormon-Préiparate: Arzneimittelféilschungen in Bodybuilder-Szene”: ”The currently known cases are traded with Dutch or Russian labels…In addition to a display of labels in the Dutch or Russian language the fakes are distinguished from the original product, insofar as the dry substance is not present as lyophilic but present as loose powder. The fakes confiscated so far use the name “Humatrope 16” under the name of Lilly Company (with Dutch denomination) or ”Somatogen” (in Russian).” Nowhere can this much money be made except by faking Human Growth Hormone. Who has ever held original growth hormones in his hand and known how they should look?
4. In a few very rare cases the body reacts by developing antibodies to the exogenous Human Growth Hormone,
thus making it ineffective.
HGH, Insulin and LT-3
These are human growth hormone, insulin, and an LT—3 thyroid hormone, such as, for example, Tertroxin. Only then can the liver produce and release an optimal amount of somatomedin and insulin—like growth factors. This anabolic effect can be further enhanced by taking a substance with an anti-catabolic effect. These substances are, everybody should probably know by now, anabolic/androgenic steroids or Clenbuterol. Then a synergetic effect takes place. Are you still wondering why pro bodybuilders are so incredibly massive but, at the same time, totally ripped while you are not? It is ”Polypharmacy at its finest,” as W Nathaniel Phillips described to the point in his book “Anabolic Reference Guide (5th Issue, 1990).
But coming back once more to the “anabolic formula”: Human Growth Hormone, insulin, and L-T3. Most athletes have tried Human Growth Hormone during preparation for a competition in that phase when the diet is calorie-reduced. The body usually reacts by reducing the release of insulin and of the L-T3 thyroid hormone. And, as was described under point 2, this is not an advantageous condition when STH is expected to work well.
It is important to note that those who combine Clenbuterol with Human Growth Hormone should know that Clenbuterol (like Ephedrine) reduces the body’s own release of insulin and L-T3. True, this seems a little complicated and when reading it for the first time it might be a little confusing; however it really is true: Human Growth Hormone has a significant inﬂuence on several hormones in the human body; this does not allow for a simple administration schedule. As said, Human Growth Hormone is not cheap and those who intend to use it should know a little more about it. If you only want to burn fat with Human Growth Hormone you will only have to remember user information for the part with the L—T3 thyroid hormone as is printed by Kabi Pharmacia GmbH for their compound Genotropin: “The need of the thyroid hormone often increases during treatment with human growth hormones.”
Since most athletes who want to use Human Growth Hormone can only obtain it if prescribed by a physician, the only supply source remains the black market. And this is certainly another reason why some athletes might not have been very happy with the effect of the purchased compound. How could he, if cheap HCG was passed off as expensive Human Growth Hormone? Since both compounds are available as dry substances, all that would be needed is a new label of Serono’s Saizen or Lilly’s Humatrope on the HCG ampule. It is no longer fun when somebody is paying $200 for 5000 LU. of HCG, only worth 35 12, and thinking that he just purchased 4 1.11. of Human Growth Hormone. And if you think this happens only to novices and to the ignorant, ask Ben Johnson. ”Big Ben,” who during three tests within five days showed an above-limit testosterone level, was not a victim of his own stupidity but more likely the victim of fraud.
Before discussing the extremely difficult matter of dosage and intake the following question suggests itself: Generally speaking who is taking human growth hormone? A whole lot of athletes as the following quotation suggests: ”Char1ie Francis, the Canadian athletic trainer of Ben Johnson tells how he improved the performance of Ben and numerous other Olympic athletes by the use of human growth hormone in 1983. Francis also had conclusive evidence that the U.S. -American field and track athletes were using human growth hormone. In a 1989 interview with a pro bodybuilder, an interview not meant for publication, this massive athlete made clear that he was convinced that almost all professional top athletes were using Protropin. He also said that it did not bother him if the IFBB were to introduce doping tests for men in 1990 as long as there would be no testing for human growth hormone (Anabolic Reference Update, June 1989, no. 11).
”It is highly suspected that the top Ms. O competitors use this product to help them attain their incredibly rippled muscles while still looking like women.” (Anabolic Reference Guide, 5th Issue, 1990, W N. Phillips.) Most top bodybuilders using Human Growth Hormone (GH) feel that insulin activates it. One top pro was rumored to have been using 12 IU of Human Growth Hormone per day in preparation for his last WBF contest. He swears that Human Growth Hormone only works with insulin.” (Muscle Media 2000, October/November 1993, no. 34.)” And shortly before the 1984 Olympic Games in Los Angeles, U.S. researchers succeeded in synthetically manufacturing the hormone.
This hormone which cannot be detected with current testing methods immediately -prepared American athletes throughout the country for the games in California. After reports of success the drug became the secret runner on the doping market. The football pro Lyle Alzado, who died of brain tumor, shortly before his death confessed that he had taken Human Growth Hormone for 16 weeks, and he claimed that 80% of all American football pros do so, too. Ben Johnson, who in 1988 in Seoul was caught with an, admitted to the investigating committee of the Canadian government that he had tried the Human Growth Hormone.
He had paid $10,000 for ten bottles of HGH. According to Johnson, his physician, George Astaphan, had also designed programs for his colleagues Mark McKoy, Angella Issaj enko, and Desai Williams. Hurdle sprinter Juli Rochelean who today runs records for Switzerland under the name Baumann procured Human Growth Hormone on the black market of the bodybuilder scene in Montreal… Among women Gail Devers won the 100 meters (1992 Olympic Games in Barcelona, the auth.) after having just overcome a severe thyroid condition, a well known side effect of taking Human Growth Hormone. Such suspicions are
reinforced by current market data.
The two US. companies Genentech and Eli Lilly produced about 800 million dollars of HGH in 1992. Genentech alone reported an eleven percent production increase compared to last year. Chemists incessantly emphasize that the drug should only be manufactured for use by persons with stunted growth. The U.S.Food and Drug Administration, however, sees it differently: the 11.5. government currently includes Human Growth Hormone on the list of forbidden drugs and threatens up to five years of prison for illegal possession of the drug.” (Der Spiegel, no. 1 1 of 03/ 1 5/ 93). ”Many of the top strength athletes use Human Growth Hormone and the cost of its use ran as high as $30,000/year for one particular pro bodybuilder. Short term users (8 week duration) will spend up to $150 per daily dosage. And because the top athletes are rumored to use it, Human Growth Hormone lust in the lower ranks has become more rampant.” (Daniel Duchaine, Underground Steroid Hand-book 2.)
The question of the right dosage, as well as the type and duration of application, is very difficult to answer. Since there is no scientific research showing how Human Growth Hormone should be taken for performance improvement, we can only rely on empirical data, that is experimental values. The respective manufacturers indicate that in cases of hypo-physically stunted growth due to lacking or insufficient release of human growth hormone by the hypophysis, a weekly average dose of 0.3 IU/week per pound of body weight should be taken. An athlete weighing 200 pounds, therefore, would have to inject 60 IU weekly. The dosage would be divided into three intramuscular injections of 2 IU each. Subcutaneous injections (under the skin) are another form of intake which, however, would have to be injected daily, usually 8 IU per day. Top athletes usually inject 4-16 IU/day.
Ordinarily, daily subcutaneous injections are preferred. Since Human Growth Hormone has a half-life time of less than one hour, it is not surprising that some athletes divide their daily dose into three or four subcutaneous injections of 2-4 IU each. Application of regular, small dosages seems to bring the most effective results. This also has its reasons: When Human Growth Hormone is injected, serum concentration in the blood rises quickly, meaning that the effect is almost immediate. As we know, Human Growth Hormone stimulates the liver to produce and release somatomedins and insulin-like growth factors which in turn affect the desired results in the body.
Since the liver can only produce a limited amount of these substances, we doubt that larger Human Growth Hormone injections will induce the liver to produce instantaneously a larger quantity of somatomedins and insulin—like growth factors. It seems more likely that the liver will react more favorably to smaller dosages.
If the Human Growth Hormone solution is injected subcutaneously several consecutive times at the same point of injection, a loss of fat tissue is possible. Therefore, the point of injection, or even better, the entire side of the body, should be continuously changed in order to avoid a loss of local fat tissue (lipoatrophy) in the injection cell. One thing has manifested itself over the years: The effect of Human Growth Hormone is dosage dependent. This means either invest a lot of money and do it right or do not even begin. Half-hearted attempts are condemned to failure. Minimum effective dosages seem to start at 4 I.U. per day.
For comparison: the hypophysis of a healthy, adult releases 0.5-1.5 IU growth hormones daily. The duration of intake usually depends on the athlete’s financial resources. Our experience is that Human Growth Hormone is taken over a prolonged period, from at least six weeks to several months. It is interesting to note that the effect of STH does not stop after a few weeks; this usually allows for continued improvements at a steady dosage. Bodybuilders who have had positive results with STH have reported that the built-up strength and, in particular, the newly-gained muscle system were essentially maintained after discontinuance of the product.
The American physician, Dr. William N. Taylor, confirms this statement in his book Anabolic Steroids and the Athlete, where on page 75 he writes: ”Evidence for increased muscle number (hyperplasia) in athletes stems from their statements that the increased muscular size and strength remain after the HGH therapy has been discontinued. In fact, there may be further muscular size and strength gains as the training-induced hypertrophy continues in the month beyond.”
It remains to be clarified what happens with the insulin and LT-3 thyroid hormone. Athletes who take STH in their build-up phase usually do not need exogenous insulin. It is recommended, in this case, that the athlete eats a complete meal every three hours, resulting in 6-7 meals daily. This causes the body to continuously release insulin so that the blood sugar level does not fall too low. The use of LT-3 thyroid hormones, in this phase, is carried out reluctantly by athletes. In any case, you must have a physician check the thyroid hormone level during the intake of STH. Simultaneous use of anabolic/androgenic steroids and/or Clenbuterol is usually appropriate.
During the preparation for a competition the use of thyroid hormones steadily increases. Sometimes insulin is taken together with Human Growth Hormone, as well as with steroids and Clenbuterol. Apart from the high damage potential that exogenous insulin can have in non-diabetics, incorrect use will simply and plainly make you FAT! Too much insulin activates certain enzymes which convert glucose into glycerol and finally into triglyceride. Too little insulin, especially during a diet, reduces the anabolic effect of STH. The solution to this dilemma? Visiting a qualified physician who advises the athlete during this undertaking and who, in the event of exogenous insulin supply, checks the blood sugar level and urine periodically.
According to what we have heard so far, athletes usually inject intermediately-effective insulin having a maximum duration of effect of 24 hours once a day. Human insulin such as Depot-H. Insulin Hoechst is generally used. Briefly, effective insulin with a maximum duration of effect of eight hours is rarely used by athletes. Again a human insulin such as H-Insulin Hoechst is preferred.
The undesired effect of human growth hormone, the so-called side effects, are also a very interesting and hotly-discussed issue. Above all it must be said: Human Growth Hormone has none of the typical side effects of anabolic/androgenic steroids including reduced endogenous testosterone production, acne, hair loss, aggressiveness, elevated estrogen level, virilization symptoms in women, and increased water and salt retention. The main side effects that are possible with Human Growth Hormone are abnormally small concentration of glucose in the blood (hypoglycemia) and an inadequate thyroid function.
In some cases antibodies against growth hormones are developed but are clinically irrelevant. What about the horror stories about acromegaly, bone deformation, heart enlargement, organ conditions, gigantism, and early death? In order to answer this question a clear differentiation must be made between humans before and after puberty. The growth plates in a person continue to grow in length until puberty. After puberty neither an endogenous hyper-section of human growth hormone nor an excessive exogenous supply of Human Growth Hormone can cause additional growth in the length of the bones. Abnormal size (gigantism) initially goes hand in hand with remarkable body strength and muscular hardness in the afflicted; later, if left untreated, it ends in weakness and death.
Again, this is only possible in pre-pubescent humans who also suffer from an inadequate gonadal function (hypogonadism). Humans who suffer from an endogenous hyper-secretion after puberty and whose normal growth is completed can also suffer from acromegaly. Bones become wider but not longer. There is a progressive growth in the hands and feet, and enlargement of features due to the growth of the lower jaw and nose.
Heart muscle and kidneys can also gain in weight and size. In the beginning all of this goes hand in hand with increased body strength and muscular hardness; it ends, however, in fatigue, weakness, diabetes, heart conditions, and early death.
What the authorities like to do now is to present extreme cases of athletes suffering from these malfunctions in order to discourage others and to drum into athletes the fact that with the exogenous supply of human growth hormone they would suffer the same destiny.
This, however, is very unlikely, as reality has proven. Among the numerous athletes using Human Growth Hormone comparatively few are seven feet tall Neanderthals with a protruded lower jaw, deformed skull, claw-like hands, thick lips, and prominent bone plates who walk around in size 25 shoes. In order to avoid any misunderstandings, we do not want to disguise the possible risks of exogenous Human Growth Hormone use in adults and healthy humans, but one should at least try to be open minded.
Acromegaly, diabetes, thyroid insufficiency, heart muscle hypertrophy, high blood pressure, and enlargement of the kidneys are theoretically possible if Human Growth Hormone is used excessively over prolonged periods of time; however, in reality and particularly when it comes to the external attributes, these are rarely present. Tests have shown no causal relation between treatment with Somatropin and a possible higher risk of leukemia. Some athletes report headaches, nausea, vomiting, and visual disturbances during the first weeks of intake. These symptoms disappear in most cases even with continued intake. The most common problems with STH occur when the athlete intends to inject insulin in addition to STH. We know two competing German bodybuilders who, because of improper insulin injections, fell into comas lasting several weeks.
The substance Human Growth Hormone (Somatropin) is available as a dried powder and before injecting it must be mixed with the enclosed solution, containing ampule. The ready solution must be injected immediately or stored in the refrigerator for up to 24 hours. It is usually recommended that the compound be stored in the refrigerator. With the exception of the remedy Saizen the biological activity of growth hormones is usually not impaired when storing the dry substance at 15—25° C (room temperature); however, a cooler place (2—8‘’ C) is preferable.
Availible Human Growth Hormone Versions
Medical Uses and Information – Uses/side-effects/interactions/overdose
Various brands of this medication are used for the treatment of one of the following medical conditions: growth failure, growth hormone deficiency, intestinal disorder (short bowel syndrome) or HIV-related weight loss or wasting.
How to use Somatropin Solution, Reconstituted (Recon Soln)
Read the Patient Information Leaflet that may come with your brand of this medication provided by your pharmacist before you start using somatropin and each time you get a refill. If you have any questions, consult your doctor or pharmacist.
Some brands of this medication are given by injection into a muscle or under the skin. Some brands may only be injected under the skin. The way you inject this medicine will depend on the brand that you are using. Check with your pharmacist to ensure that the way you are injecting your medicine is correct. It is important to change the location of the injection site to avoid problem areas under the skin. For best results, this medication must be used exactly as prescribed by your doctor. It is important to understand your therapy and to follow your doctor’s instructions closely.
The dosage is based on your age, weight, medical condition and response to treatment.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Do not shake while mixing the solution. Shaking makes the medication not work properly. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
If this medicine is used for short bowel syndrome, consult your doctor if a special diet (high carbohydrate/low-fat) or the use of nutritional supplements may be helpful.
If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug. Do not use more of this medication
Headache, nausea, vomiting, fatigue, muscle pain, or weakness may occur. If these symptoms continue or become bothersome, inform your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: development of a limp, persistent fatigue, unusual/unexplained weight gain, persistent cold intolerance, persistent slow heartbeat, fast heartbeat, ear pain/itching, hearing problems, joint/hip/knee pain, numbness/tingling, unusual increase in thirst or urination, swelling hands/ankles/feet, change in the appearance or size of any mole, persistent nausea/vomiting, severe stomach/abdominal pain.
Get medical help right away if you have any very serious side effects, including: vision problems/changes, seizure, severe headache.
Rare (possibly fatal) lung/breathing problems may be caused by this medication in children with Prader-Willi syndrome. Those at higher risk include males, severely overweight children, or those with serious lung/breathing problems ( e.g., sleep apnea, lung infections, lung disease). Children should be checked for certain breathing problems (upper airway obstruction) before and during treatment. Heavy snoring or irregular breathing during sleep(sleep apnea) are signs of airway obstruction. Tell the doctor right away if these signs occur. Also report any signs of lung infection, such as fever, persistent cough, or trouble breathing.
Human Growth Hormone may increase your risk of getting a tumor or cancer. Discuss the details and the risks and benefits of this medication with your doctor.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: rash, itching/severe swelling (especially of the face/tongue/throat), dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Before using Human Growth Hormone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as benzyl alcohol or metacresol found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problems, eye problems (e.g., diabetic retinopathy), recent major surgery/injury, severe breathing problems (acute respiratory failure), diabetes or family history of diabetes, obesity, kidney disease, tumors (cancer, especially of the head/neck), thyroid problems, back problems (scoliosis).
If you have diabetes, this drug may increase your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
When this medication is given to newborns, mix with sterile water for injection that does not contain a preservative. A preservative (benzyl alcohol) which may be found in the liquid used to mix this product can rarely cause serious problems (sometimes death), if given by injection to an infant during the first months of life. The risk is greater with lower birth weight infants and is greater with increased amounts of benzyl alcohol. Symptoms include sudden gasping, low blood pressure, or a very slow heartbeat. Report these symptoms to the doctor right away should they occur.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug, especially effects on blood sugar, or swelling ankles/feet. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: estrogen hormone replacement.