”Wow, is this great stuff. It is the best drug for permanent muscle gains. This is the only drug that can remedy bad genetics as it will make anybody grow.Human Growth Hormone use is the biggest gamble that an athlete can take, as the side effects are irreversible. Even with all that, we LOVE the stuff.” (Daniel Duchaine, Underground Steroid Handbook, 1982.)
An aura of mystery still surrounds Growth Hormone. More So than other doping drug. Some call it a wonder drug which causes gigantic strength and muscle gains in the shortest time. Others consider it completely useless in improving sports performance. They argue that it only promotes the growth process in children with an early stunting of growth. Some are of the opinion that human growth hormone in adults cause severe bone deformities in the form of overgrowth of the lower jaw and extremities.
Which growth hormone should one take? The human form? The synthetically manufactured version? Recombined or genetically produced form? And in which dosage? All this controversy about human growth hormone is complex. The reader must have some basic information in order to understand it. Human growth hormone is a polypeptide hormone consisting of 191 amino acids. The human hypophysis is where production takes place. With the right stimuli (e.g. training, sleep, stress, low blood sugar level) release takes place from here. It is now important to understand that the free HGH (human growth hormone) itself has no direct effect. I only stimulates the liver to produce and release insulin—like growth factors and somatomedins. These growth factors are then the ones that cause Various effects on the body.
The problem, however, is that the liver is only capable of producing a limited amount of these substances so that the effect is limited. Injected human growth hormone only stimulates the liver to produce and release these substances. It has no direct effect.
During the mid 1980’s only the human, biologically—active form was available as exogenous source of intake. An expensive and costly procedure obtained it from the hypophysis of dead corpses. In 1985 the rare Creutzfeld-Jakob disease was linked to the intake of human growth hormone. Inevitably fatal characterized by progressive dementia. In response, manufacturers removed this version from the market. Today, human growth hormone is no longer available for injection. Fortunately, science has not been asleep and has developed the synthetic human growth hormone which is genetically produced either from Escherichia coli (E coli) or from the transformed mouse ceH line. It has been available in numerous countries for years (see list with trade names).
The use of these STH somatotropic hormone compounds offers the athlete three performance—enhancing effects. Human Growth Hormone (somatotropic hormone) has a strong anabolic effect and causes an increased protein synthesis which manifests itself in a muscular hypertrophy (enlargement of muscle cells) and in a muscular hyperplasia (increase of muscle cells.) The latter is very interesting since this increase cannot be obtained by the intake of steroids. This is also why STH is called the “strongest anabolic hormone”.
The second effect of Human Growth Hormone is its pronounced inﬂuence on the burning of fat. It turns more body fat into energy, leading to a drastic reduction in fat or allowing the athlete to increase his caloric intake. Third, and often overlooked, is the fact that Human Growth Hormone strengthens the connective tissue, tendons, and cartilages, which could be one of the main reasons for the significant increase in strength experienced by many athletes.
When no benefits are experienced
Several bodybuilders and powerlifters report that simultaneous intake with steroids protects the athlete from injuries while increasing his strength. You will say that this sounds just wonderful. What is the problem, however, since there are still some who argue that Human Growth Hormone offers nothing to athletes? There are, by all means, several athletes who have tried Human Growth Hormone and who were sadly disappointed by its results. However, as with many things in life, there is a logical explanation or perhaps even more than one:
The athlete simply has not taken a sufficient amount of human growth hormone regularly and over a long enough period of time. Human Growth Hormone is a very expensive compound and an effective dosage is unaffordable by most people.
When using Human Growth Hormone the body also needs more thyroid hormones, insulin, corticosteroids, gonadotropins, estrogens and, what a surprise!, androgens and anabolics. This is also the reason why growth growth hormone, when taken alone, is considerably less effective. It only reaches optimum effect with added steroid intake. As well as thyroid hormones, and insulin, in particular. But we must point out in this case that human growth hormone has a predominantly anabolic effect. There are three hormones which are needed at the same time in order to allow for maximum anabolic effect.
According to statistics by the German Drug Administration, 42% of the Human Growth Hormone vials confiscated on the North American black market are fakes.” (Der Spiegel, no. 11, 1993.) One can only say, ”Poor Ben.” Even Deutsche Apothekerzeitung is aware of this problem.
The magazine wrote in its issue no. 26 of 07/01/ 93 in the article ”Wachstumshormon-Préiparate: Arzneimittelféilschungen in Bodybuilder-Szene”: ”The currently known cases are traded with Dutch or Russian labels…In addition to a display of labels in the Dutch or Russian language the fakes are distinguished from the original product, insofar as the dry substance is not present as lyophilic but present as loose powder. The fakes confiscated so far use the name “Humatrope 16” under the name of Lilly Company (with Dutch denomination) or ”Somatogen” (in Russian).” Nowhere can this much money be made except by faking Human Growth Hormone. Who has ever held original growth hormones in his hand and known how they should look?
Development of anti-bodies
In a few very rare cases the body reacts by developing antibodies to the exogenous Human Growth Hormone,
thus making it ineffective.
HGH, Insulin and LT-3
These are human growth hormone, insulin, and an LT—3 thyroid hormone, such as, for example, Tertroxin. Only then can the liver produce and release an optimal amount of somatomedin and insulin—like growth factors. This anabolic effect can be further enhanced by taking a substance with an anti-catabolic effect. These substances are, everybody should probably know by now, anabolic/androgenic steroids or Clenbuterol. Then a synergetic effect takes place. Are you still wondering why pro bodybuilders are so incredibly massive but, at the same time, totally ripped while you are not? It is ”Polypharmacy at its finest,” as W Nathaniel Phillips described to the point in his book “Anabolic Reference Guide (5th Issue, 1990).
But coming back once more to the “anabolic formula”: Human Growth Hormone, insulin, and L-T3. Most athletes have tried Human Growth Hormone during preparation for a competition. During the phase when the diet is calorie-reduced. The body usually reacts by reducing the release of insulin and of the L-T3 thyroid hormone. And, as was described under point 2, this is not an advantageous condition when STH is expected to work well.
It is important to note that those who combine Clenbuterol with Human Growth Hormone should know that Clenbuterol (like Ephedrine) reduces the body’s own release of insulin and L-T3. True, this seems a little complicated and when reading it for the first time it might be a little confusing; however it really is true: Human Growth Hormone has a significant inﬂuence on several hormones in the human body; this does not allow for a simple administration schedule.
As said, Human Growth Hormone is not cheap and those who intend to use it should know a little more about it. If you only want to burn fat with Human Growth Hormone you will only have to remember user information for the part with the L—T3 thyroid hormone as is printed by Kabi Pharmacia GmbH for their compound Genotropin: “The need of the thyroid hormone often increases during treatment with human growth hormones.”
Most athletes who want to use Human Growth Hormone can only get it if prescribed by a physician. The only source of supply remains the black market. Another reason athletes might not have happy with the effect of the purchased compound. How could he, if cheap HCG was being passed off as expensive Human Growth Hormone? Both compounds are available as dry substances. You need fake labels. Serono’s Saizen or Lilly’s Humatrope on the HCG ampule.
It is no longer fun when somebody is paying $200 for 5000 LU. of HCG, only worth 35 12, and thinking he purchased 4 1.11. of Human Growth Hormone. And if you think this happens only to novices and to the ignorant, ask Ben Johnson. ” Big Ben,” who during three tests within five days showed an above-limit testosterone level, was not a victim of his own stupidity but more likely the victim of fraud.
Who is taking?
Before discussing the difficult matter of dosage and intake the following question arrises: who is taking human growth hormone? A lot of athletes as the following quotation suggests: ” Char1ie Francis, the Canadian athletic trainer of Ben Johnson tells how he improved performances of Ben and many other Olympic athletes by use of human growth hormone in 1983. Francis also had conclusive evidence that the U.S. American field and track athletes were using human growth hormone.
In 1989 there was an interview with a pro bodybuilder. An interview not meant for publication. Clearly convinced that most professional athletes were using Protropin. He also said it did not bother him if the IFBB were to introduce doping tests for men in 1990 as long as there would be no testing for human growth hormone (Anabolic Reference Update, June 1989, no. 11).
” I suspect that the top Ms O competitors use this product to help them attain their incredibly rippled muscles while still looking like women.” (Anabolic Reference Guide, 5th Issue, 1990, W N. Phillips.) Most top bodybuilders using Human Growth Hormone (GH) feel that insulin activates it. There were rumours that on top pro was using 12 IU of Human Growth Hormone per day. To prepare for his last WBF contest. He swears that Human Growth Hormone only works with insulin.” (Muscle Media 2000, October/November 1993, no. 34.)” And before the 1984 Olympic Games in Los Angeles, U.S. researchers succeeded in synthetic manufacturing of the hormone.
Current testing methods cannot detect this hormone. American athletes throughout the country used it in preparation for the games in California. After reports of success the drug became the secret runner on the doping market. Football pro Lyle Alzado, who died of brain tumor. Before his death confessed that he had taken Human Growth Hormone for 16 weeks, and he claimed 80% of all American football pros do so, too. Seoul 1988. Ben Johnson gets caught. He admitted to the investigating committee of the Canadian government he had tried the Human Growth Hormone.
He had paid $10,000 for ten bottles of HGH. According to Johnson, his physician, George Astaphan, had also designed programs for his colleagues Mark McKoy, Angella Issaj Enko, and Desai Williams. Hurdle sprinter Juli Rochelean who today runs records for Switzerland under the name Baumann bought Human Growth Hormone on the black market of the bodybuilder scene in Montreal… Among women Gail Devers, after having just overcome a severe thyroid condition, a well-known side effect of taking Human Growth Hormone won the 100 meters (1992 Olympic Games in Barcelona, the auth.).
Current market data enforces suspicion.
The two US. companies Genentech and Eli Lilly produced about 800 million dollars of HGH in 1992. Genentech alone reported an eleven percent production increase compared to last year. Chemists insist manufactured the drug to treat stunted growth. The U.S.Food and Drug Administration, however, sees it differently: the 11.5. government currently includes Human Growth Hormone on the list of forbidden drugs and threatens up to five years of prison for illegal possession of the drug.”
(Der Spiegel, no. 1 1 of 03/ 1 5/ 93). ”Many of the top strength athletes use Human Growth Hormone and the cost of its use ran as high as $30,000/year for one particular pro bodybuilder. Short term users (8 week duration) will spend up to $150 per daily dosage. Human Growth Hormone lust in the lower ranks has become more rampant. This is because of rumors that top athletes are using it”. (Daniel Duchaine, Underground Steroid Hand-book 2.)
The question of the right dosage, as well as the type and duration of application, is very difficult to answer. Since there is no scientific research showing how Human Growth Hormone should be taken for performance improvement, we can only rely on empirical data, that is experimental values. The respective manufacturers indicate that in cases of hypo-physically stunted growth due to lacking or insufficient release of human growth hormone by the hypophysis, a weekly average dose of 0.3 IU/week per pound of body weight should be taken.
An athlete weighing 200 pounds, therefore, would have to inject 60 IU weekly. Divided into three intramuscular injections of 2 IU each. Subcutaneous injections (under the skin) are another form of intake which, however, would have to be injected daily, usually 8 IU per day. Top athletes usually inject 4-16 IU/day.
Injecting under the skin
Preferred are daily subcutaneous injections are. Since Human Growth Hormone has a half-life time of less than one hour, it is not surprising that some athletes divide their daily dose into three or four subcutaneous injections of 2-4 IU each. Application of regular, small dosages seems to bring the most effective results. This also has its reasons. Injected Human Growth Hormone quickly raises blood serum levels. The effect is almost immediate. Human Growth Hormone stimulates the liver to produce and release somatomedins and insulin-like growth factors. These in turn affect the desired results in the body.
The liver can only produce a limited amount of these substances. We doubt larger Human Growth Hormone injections will induce the liver to produce larger quantities of somatomedins and insulin-like growth factors. It seems more likely that the liver will react more favorably to smaller dosages.
Human Growth Hormone is subcutaneously injected several times. If injected at the same point, a loss of fat tissue is possible. The entire side of the body should be continuously changed. this helps avoid a loss of local fat tissue (lipoatrophy) at the injection site. One thing has manifested itself over the years. The effect of Human Growth Hormone is dosage dependent. This means either invest a lot of money and do it right or do not even begin. Half-hearted attempts leads to failure. Minimum effective dosages seem to start at 4 I.U. per day.
The hypophysis of a healthy, adult releases 0.5-1.5 IU growth hormones daily. The duration of intake usually depends on the athlete’s financial resources. Human Growth Hormone is taken over long periods. From at least six weeks to several months. It is interesting to note that the effect of STH does not stop after a few weeks; this usually allows for continued improvements at a steady dosage. Bodybuilders who have had positive results with STH. Reported are strength build up and newly-gained muscle. Results were maintained after use.
The American physician, Dr. William N. Taylor, confirms this statement in his book Anabolic Steroids and the Athlete. On page 75 he writes: ”Evidence for increased muscle number (hyperplasia) in athletes stems from their statements that the increased muscular size and strength remain after the HGH therapy has been discontinued. In fact, there may be further muscular size and strength gains as the training-induced hypertrophy continues in the month beyond.”
LT-3 Thyroid Hormone
It remains to be clarified what happens with the insulin and LT-3 thyroid hormone. Athletes who take STH in their build-up phase usually do not need exogenous insulin. Recommended is that athletes eat a complete meal every three hours. This results in 6-7 meals daily. This causes the body to continuously release insulin so that the blood sugar level does not fall too low. Athletes in this phase, reluctantly use LT-3 thyroid hormones. In any case, you must have a physician check the thyroid hormone level during the intake of STH. Simultaneous use of anabolic/androgenic steroids and/or Clenbuterol is usually appropriate.
During the preparation for a competition the use of thyroid hormones steadily increases. Sometimes insulin is taken together with Human Growth Hormone, as well as with steroids and Clenbuterol. Insulin has a high damage potential in non-diabetics. Incorrect use will simply and plainly make you FAT! Too much insulin activates certain enzymes which convert glucose into glycerol and finally into triglyceride. Too little insulin, especially during a diet, reduces the anabolic effect of STH. The solution to this dilemma? Visiting a qualified physician who advises the athlete during this undertaking and who, in the event of exogenous insulin supply, checks the blood sugar level and urine periodically.
According to what we have heard so far, athletes usually inject intermediately-effective insulin. One having a maximum duration of effect of 24 hours once a day. Human insulin Depot-H or Hoechst Insulin are used. Athletes rarely use insulin effective for up to 8 hours. Preferred Human insulin such as H-Insulin Hoechst.
Side effects of human growth hormone interesting and hotly-discussed. Human Growth Hormone does not have typical steroid side effects. These include reduced endogenous testosterone production, acne, hair loss, aggressiveness, elevated estrogen level, virilization symptoms in women, and increased water and salt retention. The main side effects possible with Human Growth Hormone are abnormally small concentrations of glucose in the blood (hypoglycemia). Another is inadequate thyroid function.
Development of growth hormone antibodies are clinically irrelevant. What about the horror stories about acromegaly, bone deformation, heart enlargement, organ conditions, gigantism, and early death? There are differences between humans before and after puberty. The growth plates in a person continue to grow in length until puberty. After puberty neither endogenous hyper-section nor an excessive exogenous supply of Human Growth Hormone can grow bone length. Abnormal size (gigantism) initially goes hand in hand with remarkable body strength and muscular hardness in the afflicted; later, if left untreated, it ends in weakness and death.
Again, this is only possible in pre-pubescent humans who also suffer from an inadequate gonadal function (hypogonadism). Humans who suffer from an endogenous hyper-secretion after puberty and can also suffer from acromegaly. Bones become wider but not longer. There is a progressive growth in the hands and fee. Also enlargement of features due to the growth of the lower jaw and nose.
Heart and Kidneys
Heart muscle and kidneys can also gain in weight and size. In the beginning all of this goes hand in hand with increased body strength and muscular hardness; it ends, however, in fatigue, weakness, diabetes, heart conditions, and early death.
Authorities likes to present extreme cases of athletes suffering from these malfunctions in order to discourage others. They drum into athletes that with the exogenous supply of human growth hormone they would suffer the same destiny.
This, however, is very unlikely, as reality has proven. Among the numerous athletes using Human Growth Hormone comparatively few are seven feet tall Neanderthals. With a protruded lower jaw, deformed skull, claw-like hands, thick lips, and prominent bone plates. And who walk around in size 25 shoes. To avoid any misunderstandings, we do not want to disguise the possible risks of exogenous Human Growth Hormone use. At least attempt open mindedness.
Other side Effects
Acromegaly, diabetes, thyroid insufficiency, heart muscle hypertrophy, high blood pressure, and enlargement of the kidneys are possible if Human Growth Hormone. If used excessively over prolonged periods of time; however, in reality and particularly when it comes to the external attributes, these are rarely present. Tests have shown no causal relation between treatment with Somatropin and a possible higher risk of leukemia.
Some athletes report headaches, nausea, vomiting, and visual disturbances during the first weeks of intake. These symptoms disappear in most cases even with continued intake. The most common problems with STH occur when the athlete intends to inject insulin in addition to STH. We know two competing German bodybuilders who, because of improper insulin injections, fell into comas lasting several weeks.
The substance Human Growth Hormone (Somatropin) is available as a dried powder. Before injecting it must be mixed with the enclosed solution, containing ampule. Inject immediately after mixing. Then store in the refrigerator for up to 24 hours.Recommended storage is refrigeration. With exception, the remedy Saizen, biological activity remains unimpaired when storing at 15—25° C (room temperature). A cooler place (2—8‘’ C) is preferable.