Arimidex overview. Active: Letrozole
Uses in Body Building
Letrozole (Femara) and Arimidex are the two most popular aromatase inhibitors of the 3 major AIs, with Letrozole being the second most popular. Letrozole has demonstrated some very incredible efficiency in the reduction of Estrogen, more so than the other two major aromatase inhibitors. In comparison with the Arimidex, Letrozole has been found to be 10 – 20 times the strength of Arimidex, and although Letrozole doses are equally as effective as Aromasin, it operates through a different pathway in order to be highly effective in its own right. However, the context that an anabolic steroid using athlete or bodybuilder is slightly different from the medical and clinical application of Letrozole or any aromatase inhibitor, and this is what any anabolic steroid user is most concerned with: the proper Letrozole doses for Estrogen control, how to utilize Letrozole doses, and the different manners in which Letrozole doses can be used.
It must first be understood that Letrozole is an aromatase inhibitor, with a wide variety of application in terms of Estrogen control. As an aromatase inhibitor, it holds the ability to exert control over literally all of the potential Estrogenic side effects that anabolic steroid users attempt to avoid or eliminate. The standard protocol (or general rule) for the use of all aromatase inhibitors should be the following:
Attempt to avoid the use of aromatase inhibitors at all costs unless absolutely necessary. If the use of an aromatase inhibitor is necessary, utilize it only when required, and attempt the lowest possible dose for the purpose of Estrogen control rather than Estrogen elimination.
This is extremely important and must be remembered by all readers investigating the use of aromatase inhibitors. The fact of the matter is that the use of aromatase inhibitors, whether it be the three primary AIs (Arimidex, Aromasin, and Letrozole) or any others, will exert negative effects on the body if utilized when they are either unneeded, or when they are utilized too much at Letrozole doses that are too high.
Remember that the reason for the use of an aromatase inhibitor should at all times be for the purpose of Estrogen control rather than Estrogen elimination, as the complete and total reduction of all Estrogen levels in the body can and does result in deleterious effects on the human body. This will be further explained in the side effects portion of this profile, but a general description is that these compounds (aromatase inhibitors) deprive the body of a very important hormone (Estrogen) that is important for various essential bodily functions at normal physiological levels.
Letrozole Dosage During Anabolic Steroid Use
Letrozole in particular cannot be categorized into the three tiers of users (beginner, intermediate, and advanced) as normally outlined and listed in common profiles of the different compounds and drugs. This is due to the fact that Letrozole is an ancillary drug not particularly used for the purpose of performance enhancement, but instead is utilized to combat or mitigate various Estrogen-related side effects when aromatizable anabolic steroids are utilized.
In some instances, Letrozole doses might possibly also be utilized to increase the endogenous secretion of Testosterone in men, which allows this compound to be utilized as an ancillary medication during PCT (Post Cycle Therapy) phases following the end of an anabolic steroid cycle, but its use on its own for this purpose is not very common and is unlikely to produce noticeable performance enhancing effects. Letrozole’s use as an endogenous Testosterone stimulating agent will be further covered in detail shortly.
For the purpose of Estrogen control during a cycle: Letrozole is the most effective aromatase inhibitor utilized to reduce levels of circulating Estrogen in the body during a cycle involving the use of aromatizable androgens (anabolic steroids that have an affinity to bind to the aromatase enzyme and undergo aromatization into Estrogen). This has been outlined previously in the introduction. Letrozole doses for this purpose cover a very wide range, and how much Letrozole is required (and how often) is also largely dependent on the doses of aromatizable anabolic steroids used, the individual’s sensitivity to aromatase inhibitors, and the rate of aromatization of the anabolic steroids used. With this being said, the general range of Letrozole doses are approximately 1.25mg – 2.5mg daily. There does exist a very large margin for adjustment and user preference when it comes to Letrozole dosages, as each individual should slowly adjust their dose depending on how they feel the body is responding. This is especially so for Letrozole, which is the most powerful and potent AI of the three. Even 1.25mg daily is too much for many anabolic steroid users, and often times the recommended dose is actually 1.25mg every other day, and often can be even less frequent especially considering the half-life of Letrozole is that of 2 – 4 days. These Letrozole doses can easily be adjusted if the user feels it is not working well enough, or if it is reducing Estrogen levels too much.
Medical Uses/Side Effects/Precautions/Interactions with other drugs/Overdose
This product contains 2 medications: ribociclib tablets and letrozole tablets. These medications are used to treat breast cancer in women after menopause. Ribociclib works by slowing or stopping the growth of cancer cells. Letrozole works by decreasing the amount of estrogen the body makes, which helps slow down or reverse the growth of some breast cancers.
How to use Ribociclib 200 Mg/Day (200 Mg X 1) And Letrozole 2.5 Tablet
Read the Patient Information Leaflet if available from your pharmacist before you start taking ribociclib and letrozole tablets and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take ribociclib by mouth with or without food as directed by your doctor, usually once daily in the morning for 21 days, then stopping the medication for 7 days. Take letrozole by mouth with or without food as directed by your doctor, usually once daily in the morning for 28 days. This is one cycle of treatment. Continue taking these medications this way as directed by your doctor.
Swallow the tablets whole. Do not crush, chew, or break the tablets. Also, do not take a tablet that is damaged or broken.
If you vomit after taking a dose, do not take another dose on that day. Take your next dose at the regular time.
The dosage is based on your medical condition, response to treatment, lab tests, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Use these medications regularly to get the most benefit from them. To help you remember, take them at the same time(s) each day.
Do not increase your dose or use these drugs more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.
Avoid eating grapefruit or pomegranate, and avoid drinking grapefruit juice or pomegranate juice while taking these medications unless your doctor or pharmacist says you may do so safely. Grapefruit or pomegranate can increase the chance of side effects with ribociclib. Ask your doctor or pharmacist for more details.
Since these drugs can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle these medications or breathe the dust from the tablets.
Tiredness, nausea, loss of appetite, vomiting, diarrhea, headache, constipation, back pain, hot flashes, unusual sweating, dizziness, or trouble sleeping may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Temporary hair loss may occur. Normal hair growth should return after treatment has ended.
Pain or sores in the mouth and throat may occur. Brush your teeth carefully/gently, avoid using mouthwash that contains alcohol, and rinse your mouth often with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.
People using these medications may have serious side effects. However, your doctor has prescribed these drugs because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.
Tell your doctor right away if you have any serious side effects, including: bone fractures, mental/mood changes (such as depression, anxiety), swelling of arms/legs, signs of liver disease (such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).
Get medical help right away if you have any very serious side effects, including: fast/irregular heartbeat, severe dizziness, fainting.
Letrozole may rarely cause serious (sometimes fatal) problems from blood clots (such as deep vein thrombosis, heart attack, pulmonary embolism, stroke). Get medical help right away if you have: shortness of breath/rapid breathing, chest/jaw/left arm pain, confusion, pain/swelling/warmth in the groin/calf, sudden/severe headaches, trouble speaking, weakness on one side of the body, sudden vision changes.
This product may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough).
A very serious allergic reaction to these drugs is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.